In reality, you don't require all three organs in one game. It's highly recommended however if you were forced to, you could play with a prayer for an excellent RNG.

The reason why it's recommended to play each one in the same game is because the portals won't be opened more than one time. This means you can grab the 9 keys and then open them within the game and you'll be able to unlock three portals. Let's say you got Lilith and then quit the game. It's likely that to play again in the future, and when you open portals that you don't have to open the same Lilith portal.

Just a bit of math. The chances of opening portals and not being involved in the identical game are like this. First portal that you visit has a 100% probability of being right. The second portal has 67% likely of being correct. The third portal has 33% more likely to being correct, giving an overall 66.67 percent possibility of opening three portals that are not the same.

Once you've got your organs, these portals do not matter. You can play any game and combine all three organs to create the Uber Tristram portal. It's completely without any restrictions on opening portals to key players.

The gear you have set up looks great and you'll easily breeze throughout Uber Tristram. The only thing I can offer is to ensure that you make use of your potion prior to using it. Thawing and the antidote offer 50 reses for the respective ingredient in 30 second intervals. They stack up over the course of time. If you drink 20 drinks of each it will give you 10 minutes of cold and poison Res.

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